Oxaloacetate treatment preserves motor function in SOD1(G93A) mice and normalizes select neuroinflammation-related parameters in the spinal cord

Amyotrophic lateral sclerosis (ALS) remains a devastating motor neuron disease with limited treatment options. Oxaloacetate treatment has a neuroprotective effect in rodent models of seizure and neurodegeneration. Therefore, we treated the ALS model superoxide dismutase 1 (SOD1) (G93A) mice with oxa...

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Publicat a:Sci Rep
Autors principals: Tungtur, Sudheer K., Wilkins, Heather M., Rogers, Robert S., Badawi, Yomna, Sage, Jessica M., Agbas, Abdulbaki, Jawdat, Omar, Barohn, Richard J., Swerdlow, Russell H., Nishimune, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155202/
https://ncbi.nlm.nih.gov/pubmed/34040085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-90438-6
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