Impaired Mitophagy Plays a Role in Denervation of Neuromuscular Junctions in ALS Mice

Motor neurons in amyotrophic lateral sclerosis (ALS) patients and animal models show degeneration from the nerve terminal, known as dying-back neuropathy. To investigate the mechanism underlying this neuropathy, we analyzed the neuromuscular junctions (NMJs) and motor neuron cell bodies in SOD1(G93A...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Rogers, Robert S., Tungtur, Sudheer, Tanaka, Tomohiro, Nadeau, Lisa L., Badawi, Yomna, Wang, Hua, Ni, Hong-Min, Ding, Wen-Xing, Nishimune, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575151/
https://ncbi.nlm.nih.gov/pubmed/28890682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00473
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