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Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
Parkinson’s disease-causing mutations in the LRRK2 gene hyperactivate LRRK2 kinase activity and cause increased phosphorylation of Rab GTPases, important regulators of intracellular trafficking. We found that the most common LRRK2 mutation, LRRK2-G2019S, dramatically reduces the processivity of auto...
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| Publié dans: | Curr Biol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8154747/ https://ncbi.nlm.nih.gov/pubmed/33765413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2021.02.061 |
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