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Computational Model of Cardiomyocyte Apoptosis Identifies Mechanisms of Tyrosine Kinase Inhibitor-Induced Cardiotoxicity

Despite clinical observations of cardiotoxicity among cancer patients treated with tyrosine kinase inhibitors (TKIs), the molecular mechanisms by which these drugs affect the heart remain largely unknown. Mechanistic understanding of TKI-induced cardiotoxicity has been limited in part due to the com...

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Publicat a:J Mol Cell Cardiol
Autors principals: Grabowska, Monika E., Chun, Bryan, Moya, Raquel, Saucerman, Jeffrey J.
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154673/
https://ncbi.nlm.nih.gov/pubmed/33667419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2021.02.014
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