Adaptation of human iPSC-derived cardiomyocytes to tyrosine kinase inhibitors reduces acute cardiotoxicity via metabolic reprogramming

Tyrosine kinase inhibitors (TKIs) are widely used to treat solid tumors but can be cardiotoxic. The molecular basis for this toxicity and its relationship to therapeutic mechanisms remain unclear; we therefore undertook a systems-level analysis of human cardiomyocytes exposed to four TKIs. Cardiomyo...

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Vydáno v:Cell Syst
Hlavní autoři: Wang, Huan, Sheehan, Robert P., Palmer, Adam C., Everley, Robert A., Boswell, Sarah A., Ron-Harel, Noga, Ringel, Alison E., Holton, Kristina M., Jacobson, Connor A., Erickson, Alison R., Maliszewski, Laura, Haigis, Marcia C., Sorger, Peter K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657491/
https://ncbi.nlm.nih.gov/pubmed/31078528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.03.009
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