Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes

Tip60, a pan-acetyltransferase encoded by the Kat5 gene, is enriched in the myocardium; however, its function in the heart is unknown. In cancer cells, Tip60 acetylates Atm (Ataxia-telangiectasia mutated), enabling its auto-phosphorylation (pAtm), which activates the DNA damage response (DDR). It wa...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Wang, Xinrui, Lupton, Carri, Lauth, Amelia, Wan, Tina C., Foster, Parker, Patterson, Michaela, Auchampach, John A., Lough, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154663/
https://ncbi.nlm.nih.gov/pubmed/33609538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2021.02.005
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