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Potential impacts of the cardiac troponin I mobile domain on myofilament activation and relaxation

The cardiac thin filament is regulated in a Ca(2+)-dependent manner through conformational changes of troponin and tropomyosin (Tm). It has been generally understood that under conditions of low Ca(2+) the inhibitory peptide domain (IP) of troponin I (TnI) binds to actin and holds Tm over the myosin...

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Bibliografiske detaljer
Udgivet i:J Mol Cell Cardiol
Main Authors: Creso, Jenette G., Campbell, Stuart G.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154642/
https://ncbi.nlm.nih.gov/pubmed/33647310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2021.02.012
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