Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53

Ovarian cancer (OvCA) remains one of the most devastating malignancies, but treatment options are still limited. We report that amphiregulin (AREG) can serve as an effective and safe pharmacological target in a syngeneic murine model. AREG is highly abundant in abdominal fluids of patients with adva...

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Published in:Oncogene
Main Authors: Lindzen, Moshit, Ghosh, Soma, Noronha, Ashish, Drago, Diana, Nataraj, Nishanth Belugali, Leitner, Orith, Carvalho, Silvia, Zmora, Einav, Sapoznik, Stav, Shany, Keren Bahar, Levanon, Keren, Aderka, Dan, Ramírez, Belinda Sánchez, Dahlhoff, Maik, McNeish, Iain, Yarden, Yosef
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154589/
https://ncbi.nlm.nih.gov/pubmed/33941851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01784-8
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