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Exploring the Versatility of the Covalent Thiol–Alkyne Reaction with Substituted Propargyl Warheads: A Deciding Role for the Cysteine Protease
[Image: see text] Terminal unactivated alkynes are nowadays considered the golden standard for cysteine-reactive warheads in activity-based probes (ABPs) targeting cysteine deubiquitinating enzymes (DUBs). In this work, we study the versatility of the thiol–alkyne addition reaction in more depth. Co...
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| Vydáno v: | J Am Chem Soc |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Chemical
Society
2021
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8154518/ https://ncbi.nlm.nih.gov/pubmed/33885283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c10513 |
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