Exploring the Versatility of the Covalent Thiol–Alkyne Reaction with Substituted Propargyl Warheads: A Deciding Role for the Cysteine Protease

[Image: see text] Terminal unactivated alkynes are nowadays considered the golden standard for cysteine-reactive warheads in activity-based probes (ABPs) targeting cysteine deubiquitinating enzymes (DUBs). In this work, we study the versatility of the thiol–alkyne addition reaction in more depth. Co...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Mons, Elma, Kim, Robbert Q., van Doodewaerd, Bjorn R., van Veelen, Peter A., Mulder, Monique P. C., Ovaa, Huib
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2021
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154518/
https://ncbi.nlm.nih.gov/pubmed/33885283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c10513
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