Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity

Chronic infectious diseases have a substantial impact on the human B cell compartment including a notable expansion of B cells here termed atypical B cells (ABCs). Using unbiased single-cell RNA sequencing (scRNA-seq), we uncovered and characterized heterogeneities in naïve B cell, classical memory...

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Pubblicato in:Sci Adv
Autori principali: Holla, Prasida, Dizon, Brian, Ambegaonkar, Abhijit A., Rogel, Noga, Goldschmidt, Ella, Boddapati, Arun K., Sohn, Haewon, Sturdevant, Dan, Austin, James W., Kardava, Lela, Yuesheng, Li, Liu, Poching, Moir, Susan, Pierce, Susan K., Madi, Asaf
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2021
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8153733/
https://ncbi.nlm.nih.gov/pubmed/34039612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg8384
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