Malaria-induced interferon-γ drives the expansion of Tbet(hi) atypical memory B cells

Many chronic infections, including malaria and HIV, are associated with a large expansion of CD21(−)CD27(−) ‘atypical’ memory B cells (MBCs) that exhibit reduced B cell receptor (BCR) signaling and effector functions. Little is known about the conditions or transcriptional regulators driving atypica...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Obeng-Adjei, Nyamekye, Portugal, Silvia, Holla, Prasida, Li, Shanping, Sohn, Haewon, Ambegaonkar, Abhijit, Skinner, Jeff, Bowyer, Georgina, Doumbo, Ogobara K., Traore, Boubacar, Pierce, Susan K., Crompton, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633206/
https://ncbi.nlm.nih.gov/pubmed/28953967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006576
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