Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

Protective antibodies in Plasmodium falciparum malaria are only acquired after years of repeated infections. Chronic malaria exposure is associated with a large increase in atypical memory B cells (MBCs) that resemble B cells expanded in a variety of persistent viral infections. Understanding the fu...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Portugal, Silvia, Tipton, Christopher M, Sohn, Haewon, Kone, Younoussou, Wang, Jing, Li, Shanping, Skinner, Jeff, Virtaneva, Kimmo, Sturdevant, Daniel E, Porcella, Stephen F, Doumbo, Ogobara K, Doumbo, Safiatou, Kayentao, Kassoum, Ongoiba, Aissata, Traore, Boubacar, Sanz, Inaki, Pierce, Susan K, Crompton, Peter D
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2015
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444601/
https://ncbi.nlm.nih.gov/pubmed/25955968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07218
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