Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

Protective antibodies in Plasmodium falciparum malaria are only acquired after years of repeated infections. Chronic malaria exposure is associated with a large increase in atypical memory B cells (MBCs) that resemble B cells expanded in a variety of persistent viral infections. Understanding the fu...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Portugal, Silvia, Tipton, Christopher M, Sohn, Haewon, Kone, Younoussou, Wang, Jing, Li, Shanping, Skinner, Jeff, Virtaneva, Kimmo, Sturdevant, Daniel E, Porcella, Stephen F, Doumbo, Ogobara K, Doumbo, Safiatou, Kayentao, Kassoum, Ongoiba, Aissata, Traore, Boubacar, Sanz, Inaki, Pierce, Susan K, Crompton, Peter D
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444601/
https://ncbi.nlm.nih.gov/pubmed/25955968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07218
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