Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses

Globally, there is an urgency to develop effective, low-cost therapeutic interventions for coronavirus disease 2019 (COVID-19). We previously generated the stable and ultrapotent homotrimeric Pittsburgh inhalable Nanobody 21 (PiN-21). Using Syrian hamsters that model moderate to severe COVID-19 dise...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Nambulli, Sham, Xiang, Yufei, Tilston-Lunel, Natasha L., Rennick, Linda J., Sang, Zhe, Klimstra, William B., Reed, Douglas S., Crossland, Nicholas A., Shi, Yi, Duprex, W. Paul
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8153718/
https://ncbi.nlm.nih.gov/pubmed/34039613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abh0319
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