Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance

DNA double-strand break (DSB) repair is mediated by multiple pathways. It is thought that the local chromatin context affects the pathway choice, but the underlying principles are poorly understood. Using a multiplexed reporter assay in combination with Cas9 cutting, we systematically measure the re...

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發表在:Mol Cell
Main Authors: Schep, Ruben, Brinkman, Eva K., Leemans, Christ, Vergara, Xabier, van der Weide, Robin H., Morris, Ben, van Schaik, Tom, Manzo, Stefano G., Peric-Hupkes, Daniel, van den Berg, Jeroen, Beijersbergen, Roderick L., Medema, René H., van Steensel, Bas
格式: Artigo
語言:Inglês
出版: Cell Press 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8153251/
https://ncbi.nlm.nih.gov/pubmed/33848455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.03.032
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