Strain-release 2-azaallyl anion addition/borylation of [1.1.1]propellane: synthesis and functionalization of benzylamine bicyclo[1.1.1]pentyl boronates

We report a 3-component reaction between N-benzyl ketimines, [1.1.1]propellane, and pinacol boronates to generate benzylamine bicyclo[1.1.1]pentane (BCP) pinacol boronates. These structures are analogous to highly sought diarylmethanamine cores, which are common motifs in bioactive molecules. We dem...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chem Sci
Hauptverfasser: Shelp, Russell A., Ciro, Anthony, Pu, Youge, Merchant, Rohan R., Hughes, Jonathan M. E., Walsh, Patrick J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society of Chemistry 2021
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8153217/
https://ncbi.nlm.nih.gov/pubmed/34123334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc01349a
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge