Strain-release 2-azaallyl anion addition/borylation of [1.1.1]propellane: synthesis and functionalization of benzylamine bicyclo[1.1.1]pentyl boronates

We report a 3-component reaction between N-benzyl ketimines, [1.1.1]propellane, and pinacol boronates to generate benzylamine bicyclo[1.1.1]pentane (BCP) pinacol boronates. These structures are analogous to highly sought diarylmethanamine cores, which are common motifs in bioactive molecules. We dem...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Shelp, Russell A., Ciro, Anthony, Pu, Youge, Merchant, Rohan R., Hughes, Jonathan M. E., Walsh, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2021
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8153217/
https://ncbi.nlm.nih.gov/pubmed/34123334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc01349a
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