Involvement of PI3K Pathway in Glioma Cell Resistance to Temozolomide Treatment

The aim of the study was to investigate the anticancer potential of LY294002 (PI3K inhibitor) and temozolomide using glioblastoma multiforme (T98G) and anaplastic astrocytoma (MOGGCCM) cells. Apoptosis, autophagy, necrosis, and granules in the cytoplasm were identified microscopically (fluorescence...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Zając, Adrian, Sumorek-Wiadro, Joanna, Langner, Ewa, Wertel, Iwona, Maciejczyk, Aleksandra, Pawlikowska-Pawlęga, Bożena, Pawelec, Jarosław, Wasiak, Magdalena, Hułas-Stasiak, Monika, Bądziul, Dorota, Rzeski, Wojciech, Reichert, Michał, Jakubowicz-Gil, Joanna
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8152763/
https://ncbi.nlm.nih.gov/pubmed/34068110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105155
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