Involvement of PI3K Pathway in Glioma Cell Resistance to Temozolomide Treatment

The aim of the study was to investigate the anticancer potential of LY294002 (PI3K inhibitor) and temozolomide using glioblastoma multiforme (T98G) and anaplastic astrocytoma (MOGGCCM) cells. Apoptosis, autophagy, necrosis, and granules in the cytoplasm were identified microscopically (fluorescence...

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Pubblicato in:Int J Mol Sci
Autori principali: Zając, Adrian, Sumorek-Wiadro, Joanna, Langner, Ewa, Wertel, Iwona, Maciejczyk, Aleksandra, Pawlikowska-Pawlęga, Bożena, Pawelec, Jarosław, Wasiak, Magdalena, Hułas-Stasiak, Monika, Bądziul, Dorota, Rzeski, Wojciech, Reichert, Michał, Jakubowicz-Gil, Joanna
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8152763/
https://ncbi.nlm.nih.gov/pubmed/34068110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105155
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