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Inhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as antagonists of the glucose transporter GLUT1
We report on aromatic N-glucosides that inhibit selectively the cancer metabolism via two coexistent mechanisms: by initial deprivation of the glucose uptake through competitive binding in the glucose binding pocket of GLUT1 and by formation of a sequestering nanoscale supramolecular network at the...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Chem Sci |
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| Κύριοι συγγραφείς: | , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
The Royal Society of Chemistry
2020
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8152665/ https://ncbi.nlm.nih.gov/pubmed/34094062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc00954g |
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