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Inhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as antagonists of the glucose transporter GLUT1

We report on aromatic N-glucosides that inhibit selectively the cancer metabolism via two coexistent mechanisms: by initial deprivation of the glucose uptake through competitive binding in the glucose binding pocket of GLUT1 and by formation of a sequestering nanoscale supramolecular network at the...

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Publicat a:Chem Sci
Autors principals: Brito, Alexandra, Pereira, Patrícia M. R., Soares da Costa, Diana, Reis, Rui L., Ulijn, Rein V., Lewis, Jason S., Pires, Ricardo A., Pashkuleva, Iva
Format: Artigo
Idioma:Inglês
Publicat: The Royal Society of Chemistry 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8152665/
https://ncbi.nlm.nih.gov/pubmed/34094062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc00954g
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