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Thermodynamic consequences of Tyr to Trp mutations in the cation–π-mediated binding of trimethyllysine by the HP1 chromodomain

Evolution has converged on cation–π interactions for recognition of quaternary alkyl ammonium groups such as trimethyllysine (Kme3). While computational modelling indicates that Trp provides the strongest cation–π interaction of the native aromatic amino acids, there is limited corroborative data fr...

詳細記述

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書誌詳細
出版年:Chem Sci
主要な著者: Krone, Mackenzie W., Albanese, Katherine I., Leighton, Gage O., He, Cyndi Qixin, Lee, Ga Young, Garcia-Borràs, Marc, Guseman, Alex J., Williams, David C., Houk, K. N., Brustad, Eric M., Waters, Marcey L.
フォーマット: Artigo
言語:Inglês
出版事項: The Royal Society of Chemistry 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8152637/
https://ncbi.nlm.nih.gov/pubmed/34109021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc00227e
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