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Thermodynamic consequences of Tyr to Trp mutations in the cation–π-mediated binding of trimethyllysine by the HP1 chromodomain
Evolution has converged on cation–π interactions for recognition of quaternary alkyl ammonium groups such as trimethyllysine (Kme3). While computational modelling indicates that Trp provides the strongest cation–π interaction of the native aromatic amino acids, there is limited corroborative data fr...
Shranjeno v:
| izdano v: | Chem Sci |
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| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Royal Society of Chemistry
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8152637/ https://ncbi.nlm.nih.gov/pubmed/34109021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc00227e |
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