Thermodynamic consequences of Tyr to Trp mutations in the cation–π-mediated binding of trimethyllysine by the HP1 chromodomain

Evolution has converged on cation–π interactions for recognition of quaternary alkyl ammonium groups such as trimethyllysine (Kme3). While computational modelling indicates that Trp provides the strongest cation–π interaction of the native aromatic amino acids, there is limited corroborative data fr...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Krone, Mackenzie W., Albanese, Katherine I., Leighton, Gage O., He, Cyndi Qixin, Lee, Ga Young, Garcia-Borràs, Marc, Guseman, Alex J., Williams, David C., Houk, K. N., Brustad, Eric M., Waters, Marcey L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2020
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8152637/
https://ncbi.nlm.nih.gov/pubmed/34109021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc00227e
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