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Investigation of Trimethyllysine Binding by the HP1 Chromodomain via Unnatural Amino Acid Mutagenesis
Trimethyllysine (Kme3) reader proteins are targets for inhibition due to their role in mediating gene expression. Although all such reader proteins bind Kme3 in an aromatic cage, the driving force for binding may differ; some readers exhibit evidence for cation–π interactions whereas others do not....
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6040664/ https://ncbi.nlm.nih.gov/pubmed/29111699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09223 |
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