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Continual proteomic divergence of HepG2 cells as a consequence of long-term spheroid culture

Three-dimensional models are considered a powerful tool for improving the concordance between in vitro and in vivo phenotypes. However, the duration of spheroid culture may influence the degree of correlation between these counterparts. When using immortalised cell lines as model systems, the assump...

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Publicat a:Sci Rep
Autors principals: Ellero, Andrea Antonio, van den Bout, Iman, Vlok, Maré, Cromarty, Allan Duncan, Hurrell, Tracey
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149451/
https://ncbi.nlm.nih.gov/pubmed/34035320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89907-9
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