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Continual proteomic divergence of HepG2 cells as a consequence of long-term spheroid culture

Three-dimensional models are considered a powerful tool for improving the concordance between in vitro and in vivo phenotypes. However, the duration of spheroid culture may influence the degree of correlation between these counterparts. When using immortalised cell lines as model systems, the assump...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ellero, Andrea Antonio, van den Bout, Iman, Vlok, Maré, Cromarty, Allan Duncan, Hurrell, Tracey
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149451/
https://ncbi.nlm.nih.gov/pubmed/34035320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89907-9
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