A robust photoluminescence screening assay identifies uracil-DNA glycosylase inhibitors against prostate cancer

Many cancers have developed resistance to 5-FU, due to removal by the enzyme uracil-DNA glycosylase (UDG), a type of base excision repair enzyme (BER) that can excise uracil and 5-fluorouracil (5-FU) from DNA. However, the development of UDG inhibitor screening methods, especially for the rapid and...

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Dettagli Bibliografici
Pubblicato in:Chem Sci
Autori principali: Li, Guodong, Henry, Stuart Adam, Liu, Hao, Kang, Tian-Shu, Nao, Sang-Cuo, Zhao, Yichao, Wu, Chun, Jin, Jianwen, Zhang, Jia-Tong, Leung, Chung-Hang, Wai Hong Chan, Philip, Ma, Dik-Lung
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Royal Society of Chemistry 2020
Soggetti:
Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8148385/
https://ncbi.nlm.nih.gov/pubmed/34123270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc05623h
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