Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy

There is an alarming scarcity of novel chemical matter with bioactivity against multidrug-resistant Gram-negative bacterial pathogens. Cystobactamids, recently discovered natural products from myxobacteria, are an exception to this trend. Their unusual chemical structure, composed of oligomeric para...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Testolin, Giambattista, Cirnski, Katarina, Rox, Katharina, Prochnow, Hans, Fetz, Verena, Grandclaudon, Charlotte, Mollner, Tim, Baiyoumy, Alain, Ritter, Antje, Leitner, Christian, Krull, Jana, van den Heuvel, Joop, Vassort, Aurelie, Sordello, Sylvie, Hamed, Mostafa M., Elgaher, Walid A. M., Herrmann, Jennifer, Hartmann, Rolf W., Müller, Rolf, Brönstrup, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2019
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8148378/
https://ncbi.nlm.nih.gov/pubmed/34123255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc04769g
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