The nuclear export inhibitor aminoratjadone is a potent effector in extracellular-targeted drug conjugates

The concept of targeted drug conjugates has been successfully translated to clinical practice in oncology. Whereas the majority of cytotoxic effectors in drug conjugates are directed against either DNA or tubulin, our study aimed to validate nuclear export inhibition as a novel effector principle in...

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Publicado en:Chem Sci
Autores principales: Klahn, Philipp, Fetz, Verena, Ritter, Antje, Collisi, Wera, Hinkelmann, Bettina, Arnold, Tatjana, Tegge, Werner, Rox, Katharina, Hüttel, Stephan, Mohr, Kathrin I., Wink, Joachim, Stadler, Marc, Wissing, Josef, Jänsch, Lothar, Brönstrup, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540907/
https://ncbi.nlm.nih.gov/pubmed/31191875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc05542d
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