The nuclear export inhibitor aminoratjadone is a potent effector in extracellular-targeted drug conjugates

The concept of targeted drug conjugates has been successfully translated to clinical practice in oncology. Whereas the majority of cytotoxic effectors in drug conjugates are directed against either DNA or tubulin, our study aimed to validate nuclear export inhibition as a novel effector principle in...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Klahn, Philipp, Fetz, Verena, Ritter, Antje, Collisi, Wera, Hinkelmann, Bettina, Arnold, Tatjana, Tegge, Werner, Rox, Katharina, Hüttel, Stephan, Mohr, Kathrin I., Wink, Joachim, Stadler, Marc, Wissing, Josef, Jänsch, Lothar, Brönstrup, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540907/
https://ncbi.nlm.nih.gov/pubmed/31191875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc05542d
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