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Shaker-IR K(+) channel gating in heavy water: Role of structural water molecules in inactivation

It has been reported earlier that the slow (C-type) inactivated conformation in K(v) channels is stabilized by a multipoint hydrogen-bond network behind the selectivity filter. Furthermore, MD simulations revealed that structural water molecules are also involved in the formation of this network loc...

詳細記述

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書誌詳細
出版年:J Gen Physiol
主要な著者: Szanto, Tibor G., Gaal, Szabolcs, Karbat, Izhar, Varga, Zoltan, Reuveny, Eitan, Panyi, Gyorgy
フォーマット: Artigo
言語:Inglês
出版事項: Rockefeller University Press 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8148028/
https://ncbi.nlm.nih.gov/pubmed/34014250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012742
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