Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s disease

Cerebral amyloid angiopathy (CAA) contributes to accelerated cognitive decline in Alzheimer’s disease (AD) dementia and is a common finding at autopsy. The APOEε4 allele and male sex have previously been reported to associate with increased CAA in AD. To inform biomarker and therapeutic target disco...

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Publicado en:Acta Neuropathol Commun
Main Authors: Reddy, Joseph S., Allen, Mariet, Ho, Charlotte C. G., Oatman, Stephanie R., İş, Özkan, Quicksall, Zachary S., Wang, Xue, Jin, Jiangli, Patel, Tulsi A., Carnwath, Troy P., Nguyen, Thuy T., Malphrus, Kimberly G., Lincoln, Sarah J., Carrasquillo, Minerva M., Crook, Julia E., Kanekiyo, Takahisa, Murray, Melissa E., Bu, Guojun, Dickson, Dennis W., Ertekin-Taner, Nilüfer
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2021
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147512/
https://ncbi.nlm.nih.gov/pubmed/34020725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01199-2
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