Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex

The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in protein biogenesis, calcium (Ca(2+)) homeostasis, and signal transduction. Among the roughly one hundred components, which are involved in protein import and protein folding or assembly, two components stand out:...

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Bibliographic Details
Published in:Cells
Main Authors: Sicking, Mark, Lang, Sven, Bochen, Florian, Roos, Andreas, Drenth, Joost P. H., Zakaria, Muhammad, Zimmermann, Richard, Linxweiler, Maximilian
Format: Artigo
Language:Inglês
Published: MDPI 2021
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147068/
https://ncbi.nlm.nih.gov/pubmed/33925740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10051036
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