An Arrhythmic Mutation E7K Facilitates TRPM4 Channel Activation via Enhanced PIP(2) Interaction

A Ca(2+)-activated monovalent cation-selective TRPM4 channel is abundantly expressed in the heart. Recently, a single gain-of-function mutation identified in the distal N-terminus of the human TRPM4 channel (Glu(5) to Lys(5); E7K) was found to be arrhythmogenic because of enhanced cell membrane expr...

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Bibliographic Details
Published in:Cells
Main Authors: Hu, Yaopeng, Li, Qin, Kurahara, Lin-Hai, Shioi, Narumi, Hiraishi, Keizo, Fujita, Takayuki, Zhu, Xin, Inoue, Ryuji
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8146980/
https://ncbi.nlm.nih.gov/pubmed/33922380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10050983
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