Neuronal and Astrocytic Extracellular Vesicle Biomarkers in Blood Reflect Brain Pathology in Mouse Models of Alzheimer’s Disease

Circulating neuronal extracellular vesicles (NEVs) of Alzheimer’s disease (AD) patients show high Tau and β-amyloid (Aβ) levels, whereas their astrocytic EVs (AEVs) contain high complement levels. To validate EV proteins as AD biomarkers, we immunocaptured NEVs and AEVs from plasma collected from fi...

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Published in:Cells
Main Authors: Delgado-Peraza, Francheska, Nogueras-Ortiz, Carlos J., Volpert, Olga, Liu, Dong, Goetzl, Edward J., Mattson, Mark P., Greig, Nigel H., Eitan, Erez, Kapogiannis, Dimitrios
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8146429/
https://ncbi.nlm.nih.gov/pubmed/33922642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10050993
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