Surface Antigen-Guided CRISPR Screens Identify Regulators of Myeloid Leukemia Differentiation

Lack of cellular differentiation is a hallmark of many human cancers, including acute myeloid leukemia (AML). Strategies to overcome such differentiation blockade represent an approach for treating AML patients. To identify targets for differentiation based therapies, we applied an integrated cell s...

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Veröffentlicht in:Cell Stem Cell
Hauptverfasser: Wang, Eric, Zhou, Hua, Nadorp, Bettina, Cayanan, Geraldine, Chen, Xufeng, Yeaton, Anna H., Nomikou, Sofia, Witkowski, Matthew T., Narang, Sonali, Kloetgen, Andreas, Thandapani, Palaniraja, Ravn-Boess, Niklas, Tsirigos, Aristotelis, Aifantis, Iannis
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8145876/
https://ncbi.nlm.nih.gov/pubmed/33450187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.12.005
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