Surface Antigen-Guided CRISPR Screens Identify Regulators of Myeloid Leukemia Differentiation

Lack of cellular differentiation is a hallmark of many human cancers, including acute myeloid leukemia (AML). Strategies to overcome such differentiation blockade represent an approach for treating AML patients. To identify targets for differentiation based therapies, we applied an integrated cell s...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Wang, Eric, Zhou, Hua, Nadorp, Bettina, Cayanan, Geraldine, Chen, Xufeng, Yeaton, Anna H., Nomikou, Sofia, Witkowski, Matthew T., Narang, Sonali, Kloetgen, Andreas, Thandapani, Palaniraja, Ravn-Boess, Niklas, Tsirigos, Aristotelis, Aifantis, Iannis
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8145876/
https://ncbi.nlm.nih.gov/pubmed/33450187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.12.005
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