PKCα Inhibition as a Strategy to Sensitize Neuroblastoma Stem Cells to Etoposide by Stimulating Ferroptosis

Cancer stem cells (CSCs) are a limited cell population inside a tumor bulk characterized by high levels of glutathione (GSH), the most important antioxidant thiol of which cysteine is the limiting amino acid for GSH biosynthesis. In fact, CSCs over-express xCT, a cystine transporter stabilized on ce...

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Publicat a:Antioxidants (Basel)
Autors principals: Monteleone, Lorenzo, Speciale, Andrea, Valenti, Giulia Elda, Traverso, Nicola, Ravera, Silvia, Garbarino, Ombretta, Leardi, Riccardo, Farinini, Emanuele, Roveri, Antonella, Ursini, Fulvio, Cantoni, Claudia, Pronzato, Maria Adelaide, Marinari, Umberto Maria, Marengo, Barbara, Domenicotti, Cinzia
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8145544/
https://ncbi.nlm.nih.gov/pubmed/33924765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox10050691
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