PKCδ Sensitizes Neuroblastoma Cells to L-Buthionine-Sulfoximine and Etoposide Inducing Reactive Oxygen Species Overproduction and DNA Damage

Neuroblastoma is a type of pediatric cancer. The sensitivity of neuroblastoma (NB) cancer cells to chemotherapy and radiation is inhibited by the presence of antioxidants, such as glutathione (GSH), which is crucial in counteracting the endogenous production of reactive oxygen species (ROS). We have...

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Detalhes bibliográficos
Main Authors: Marengo, Barbara, De Ciucis, Chiara, Ricciarelli, Roberta, Passalacqua, Mario, Nitti, Mariapaola, Zingg, Jean-Marc, Marinari, Umberto M., Pronzato, Maria A., Domenicotti, Cinzia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034714/
https://ncbi.nlm.nih.gov/pubmed/21326872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014661
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