PKCδ Sensitizes Neuroblastoma Cells to L-Buthionine-Sulfoximine and Etoposide Inducing Reactive Oxygen Species Overproduction and DNA Damage

Neuroblastoma is a type of pediatric cancer. The sensitivity of neuroblastoma (NB) cancer cells to chemotherapy and radiation is inhibited by the presence of antioxidants, such as glutathione (GSH), which is crucial in counteracting the endogenous production of reactive oxygen species (ROS). We have...

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Главные авторы: Marengo, Barbara, De Ciucis, Chiara, Ricciarelli, Roberta, Passalacqua, Mario, Nitti, Mariapaola, Zingg, Jean-Marc, Marinari, Umberto M., Pronzato, Maria A., Domenicotti, Cinzia
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034714/
https://ncbi.nlm.nih.gov/pubmed/21326872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014661
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