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A novel target for combination immunotherapy in pancreatic cancer: IL-1β mediates immunosuppression in the tumour microenvironment

Immune checkpoint blockade (ICB) has demonstrated efficacy in multiple cancers, offering the potential of long-term disease control not achievable with cytotoxic or targeted therapies. However, the field has not yet achieved the crucial next steps — the expansion of the response rate and achievement...

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Библиографические подробности
Опубликовано в: :Br J Cancer
Главные авторы: Winograd, Rafael, Simeone, Diane M., Bar-Sagi, Dafna
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2021
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8144204/
https://ncbi.nlm.nih.gov/pubmed/33758330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-021-01303-2
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