Independent and cumulative coeliac disease-susceptibility loci are associated with distinct disease phenotypes

The phenotype of coeliac disease varies considerably for incompletely understood reasons. We investigated whether established coeliac disease susceptibility variants (SNPs) are individually or cumulatively associated with distinct phenotypes. We also tested whether a polygenic risk score (PRS) based...

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Publicado en:J Hum Genet
Autores principales: Cerqueira, Juliana X. M., Saavalainen, Päivi, Kurppa, Kalle, Laurikka, Pilvi, Huhtala, Heini, Nykter, Matti, L. E. Koskinen, Lotta, Yohannes, Dawit A., Kilpeläinen, Elina, Shcherban, Anastasia, Palotie, Aarno, Kaukinen, Katri, Lindfors, Katri
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Singapore 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8144013/
https://ncbi.nlm.nih.gov/pubmed/33446885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s10038-020-00888-5
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