Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease

Pathogenic mutations in the Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson's disease (PD). They increase its activity, resulting in augmented Rab10-Thr73 phosphorylation and conversely, LRRK2 inhibition decreases pRab10 levels. Currently, there is no assay t...

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Veröffentlicht in:Mol Cell Proteomics
Hauptverfasser: Karayel, Özge, Tonelli, Francesca, Virreira Winter, Sebastian, Geyer, Phillip E., Fan, Ying, Sammler, Esther M., Alessi, Dario R., Steger, Martin, Mann, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8143643/
https://ncbi.nlm.nih.gov/pubmed/32601174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.002055
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