Low-dose theophylline in addition to ICS therapy in COPD patients: A systematic review and meta-analysis

BACKGROUND: A synergism has been reported between theophylline and corticosteroids, wherein theophylline increases and restores the anti-inflammatory effect of inhaled corticosteroids (ICS) by enhancing histone deacetylase-2 (HDAC) activity. Several studies have explored the efficacy of low-dose the...

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Udgivet i:PLoS One
Main Authors: Shuai, Tiankui, Zhang, Chuchu, Zhang, Meng, Wang, Yalei, Xiong, Huaiyu, Huang, Qiangru, Liu, Jian
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8143407/
https://ncbi.nlm.nih.gov/pubmed/34029327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0251348
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