Low-dose theophylline in addition to ICS therapy in COPD patients: A systematic review and meta-analysis

BACKGROUND: A synergism has been reported between theophylline and corticosteroids, wherein theophylline increases and restores the anti-inflammatory effect of inhaled corticosteroids (ICS) by enhancing histone deacetylase-2 (HDAC) activity. Several studies have explored the efficacy of low-dose the...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Shuai, Tiankui, Zhang, Chuchu, Zhang, Meng, Wang, Yalei, Xiong, Huaiyu, Huang, Qiangru, Liu, Jian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8143407/
https://ncbi.nlm.nih.gov/pubmed/34029327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0251348
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