NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation

NRBF2 is a component of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex. Our previous study has revealed its role in regulating ATG14-associated PtdIns3K activity for autophagosome initiation. In this study, we revealed an unknown mechanism by which NRBF2 modulates autophagosome matur...

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Gepubliceerd in:Autophagy
Hoofdauteurs: Cai, Cui-Zan, Yang, Chuanbin, Zhuang, Xu-Xu, Yuan, Ning-Ning, Wu, Ming-Yue, Tan, Jie-Qiong, Song, Ju-Xian, Cheung, King-Ho, Su, Huanxing, Wang, Yi-Tao, Tang, Bei-Sha, Behrends, Christian, Durairajan, Siva Sundara Kumar, Yue, Zhenyu, Li, Min, Lu, Jia-Hong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2020
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8143228/
https://ncbi.nlm.nih.gov/pubmed/32543313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1760623
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