Synergistic antihyperalgesic and antinociceptive effects of morphine and methyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate (MP-III-024), a positive allosteric modulator at α2GABA(A) and α3GABA(A) receptors

RATIONALE: Opioid and GABA(A) receptors are both located in central nociceptive pathways and compounds that activate these receptors have pain-relieving properties. To date, the interactive effects of concurrent administration of these compounds in preclinical models of pain-like behaviors have not...

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Veröffentlicht in:Psychopharmacology (Berl)
Hauptverfasser: Rahman, Mohammad A., Keck, Thomas M., Poe, Michael M., Sharmin, Dishary, Cook, James M., Fischer, Bradford D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8141038/
https://ncbi.nlm.nih.gov/pubmed/33585961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-021-05791-1
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