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Synergistic antihyperalgesic and antinociceptive effects of morphine and methyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate (MP-III-024), a positive allosteric modulator at α2GABA(A) and α3GABA(A) receptors
RATIONALE: Opioid and GABA(A) receptors are both located in central nociceptive pathways and compounds that activate these receptors have pain-relieving properties. To date, the interactive effects of concurrent administration of these compounds in preclinical models of pain-like behaviors have not...
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| Publicado no: | Psychopharmacology (Berl) |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8141038/ https://ncbi.nlm.nih.gov/pubmed/33585961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-021-05791-1 |
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