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Progranulin Promotes Bone Fracture Healing via TNFR pathways in Mice with Type 2 Diabetes Mellitus

OBJECTIVES: Type 2 diabetes mellitus (T2DM) significantly increases bone fragility and fracture risk. Progranulin (PGRN) promotes bone fracture healing in both physiological and type 1 diabetic conditions. The present study aimed to investigate the role of PGRN in T2DM bone fracture healing. METHODS...

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Detalhes bibliográficos
Publicado no:Ann N Y Acad Sci
Main Authors: Ding, Yuanjing, Wei, Jianlu, Hettinghouse, Aubryanna, Li, Guangfei, Li, Xin, Einhorn, Thomas A., Liu, Chuan-ju
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138780/
https://ncbi.nlm.nih.gov/pubmed/33543485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.14568
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