Multiple sites on SARS‐CoV‐2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V

SARS‐CoV‐2 is the coronavirus responsible for the COVID‐19 pandemic. Proteases are central to the infection process of SARS‐CoV‐2. Cleavage of the spike protein on the virus's capsid causes the conformational change that leads to membrane fusion and viral entry into the target cell. Since inhib...

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Vydáno v:Protein Sci
Hlavní autoři: Bollavaram, Keval, Leeman, Tiffanie H., Lee, Maggie W., Kulkarni, Akhil, Upshaw, Sophia G., Yang, Jiabei, Song, Hannah, Platt, Manu O.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2021
Témata:
Full‐Length Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138523/
https://ncbi.nlm.nih.gov/pubmed/33786919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.4073
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