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Multiple sites on SARS‐CoV‐2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V

SARS‐CoV‐2 is the coronavirus responsible for the COVID‐19 pandemic. Proteases are central to the infection process of SARS‐CoV‐2. Cleavage of the spike protein on the virus's capsid causes the conformational change that leads to membrane fusion and viral entry into the target cell. Since inhib...

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Bibliografische gegevens
Gepubliceerd in:Protein Sci
Hoofdauteurs: Bollavaram, Keval, Leeman, Tiffanie H., Lee, Maggie W., Kulkarni, Akhil, Upshaw, Sophia G., Yang, Jiabei, Song, Hannah, Platt, Manu O.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Inc. 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138523/
https://ncbi.nlm.nih.gov/pubmed/33786919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.4073
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