Multiple sites on SARS‐CoV‐2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V

SARS‐CoV‐2 is the coronavirus responsible for the COVID‐19 pandemic. Proteases are central to the infection process of SARS‐CoV‐2. Cleavage of the spike protein on the virus's capsid causes the conformational change that leads to membrane fusion and viral entry into the target cell. Since inhib...

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Detalles Bibliográficos
Publicado en:Protein Sci
Main Authors: Bollavaram, Keval, Leeman, Tiffanie H., Lee, Maggie W., Kulkarni, Akhil, Upshaw, Sophia G., Yang, Jiabei, Song, Hannah, Platt, Manu O.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley & Sons, Inc. 2021
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Full‐Length Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138523/
https://ncbi.nlm.nih.gov/pubmed/33786919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.4073
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