FN3-based monobodies selective for the receptor binding domain of the SARS-CoV-2 spike protein

A phage library displaying 10(10) variants of the fibronectin type III (FN3) domain was affinity selected with the biotinylated form of the receptor binding domain (RBD, residues 319–541) of the SARS-CoV-2 virus spike protein. Nine binding FN3 variants (i.e. monobodies) were recovered, representing...

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Detalhes bibliográficos
Publicado no:N Biotechnol
Main Authors: Miller, Christina J., McGinnis, Jennifer E., Martinez, Michael J., Wang, Guangli, Zhou, Jian, Simmons, Erica, Amet, Tohti, Abdeen, Sanofar J., Van Huysse, James W., Bowsher, Ronald R., Kay, Brian K.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863792/
https://ncbi.nlm.nih.gov/pubmed/33556628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbt.2021.01.010
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